Everyone worries about this exact question. Over-the-counter pills while easily accessible do have side effects just as prescriptions drugs. Mixing alcohol when taking Tylenol or Ibuprofen isn't something we should do very often. Think of the time you popped a Tylenol to beat a midday headache and then got invited to drinks or it's allergy season and you're taking Claritin to beat those initial symptoms. Having one or two drinks really won't hurt you but it's important to know the specific side effects of each pill. Here's what you need to know.